5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine
CAS No.:1373621-08-9
Molecular Formula:C₃₆H₄₄N₂O₈Si
Molecular Weight:661.828
Hs Code.:

5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-<sup>(13)</sup>C-uridine

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1373621-06-7
5'-O-(4,4'-dimethoxytrityl)-6-¹³C-uridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1373621-08-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

Guidance literature:: 5'-O-(4,4'-dimethoxytrityl)-6-¹³C-uridine; With pyridine; silver nitrate; In tetrahydrofuran; for 0.5h; Darkness; Inert atmosphere;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 4h; Darkness; Inert atmosphere;
DOI:10.1021/ja302148g

Reference yield:

: 1373621-24-9
C₃₉⁽¹³⁾CH₅₂N₂O₉Si

: 1373621-08-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / acetonitrile / 3 h / Inert atmosphere

2.1: pyridine; silver nitrate / tetrahydrofuran / 0.5 h / Darkness; Inert atmosphere

2.2: 4 h / 20 °C / Darkness; Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; silver nitrate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ja302148g

Reference yield:

: 1373621-05-6
6-¹³C-uridine

: 1373621-08-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-⁽¹³⁾C-uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 5 h / 20 °C / Inert atmosphere

2.1: pyridine; silver nitrate / tetrahydrofuran / 0.5 h / Darkness; Inert atmosphere

2.2: 4 h / 20 °C / Darkness; Inert atmosphere

With pyridine; silver nitrate; In tetrahydrofuran;
DOI:10.1021/ja302148g