7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

Base Information

Chemical Name:7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid
CAS No.:1150098-40-0
Molecular Formula:C₁₅H₁₂FIN₂O₃
Molecular Weight:414.175
Hs Code.:

Synonyms:7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

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Chemical Property of 7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

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Technology Process of 7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

There total 1 articles about 7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1150098-39-7
7-chloro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

: 29632-74-4
2-fluro-4-iodoaniline

: 1150098-40-0
7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

Guidance literature:: 7-chloro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid; 2-fluro-4-iodoaniline; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 56.0%

: 391212-29-6
O-(2-vinyloxyethyl)hydroxylamine

: 1150098-40-0
7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

: 1193488-49-1
7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield: 29.6%

: 64-17-5
ethanol

: 1150098-40-0
7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

: 1193487-55-6
7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester

Guidance literature:: ethanol; 7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid; With sulfuric acid; at 85 ℃; for 72h; Inert atmosphere;

With sodium hydrogencarbonate; In ethyl acetate;