1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione)

Base Information

• Chemical Name: 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione)
• CAS No.: 1384256-61-4
• Molecular Formula: C₂₈H₂₈N₂O₄S₂
• Molecular Weight: 520.673
• Mol file: 1384256-61-4.mol

Synonyms:1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione)

Chemical Property of 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione)

There total 2 articles about 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

(Z)-3-(2,2-dichloro-2-phenylacetyl)-2-ethylidene-1,3-thiazinane (1384256-39-6) → 3-methyl-1-(3-(8-methyl-6-oxo-7-phenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-4-phenyl-1H-pyrrole-2,5-dione (1384256-62-5) + 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione) (1384256-61-4)

Guidance literature:

(Z)-3-(2,2-dichloro-2-phenylacetyl)-2-ethylidene-1,3-thiazinane; With N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride; In acetonitrile; at 30 ℃; Inert atmosphere;

With water; In acetonitrile; Inert atmosphere;

DOI:10.1016/j.tet.2012.04.117

Reference yield:

2-ethyl-5,6-dihydro-4H-[1,3]thiazine (28221-31-0) + 2,2-dichloro-2-phenylacetyl chloride (4773-36-8) → 3-methyl-1-(3-(8-methyl-6-oxo-7-phenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-4-phenyl-1H-pyrrole-2,5-dione (1384256-62-5) + 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione) (1384256-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 24.5 h / 0 - 25 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride / acetonitrile / 30 °C / Inert atmosphere

2.2: Inert atmosphere

With pyridine; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2012.04.117

upstream raw materials:

2-ethyl-5,6-dihydro-4H-[1,3]thiazine

2,2-dichloro-2-phenylacetyl chloride

(Z)-3-(2,2-dichloro-2-phenylacetyl)-2-ethylidene-1,3-thiazinane