2-Ethyl-5,6-dihydro-4H-1,3-thiazine

Base Information

• Chemical Name: 2-Ethyl-5,6-dihydro-4H-1,3-thiazine
• CAS No.: 28221-31-0
• Molecular Formula: C6H11 N S
• Molecular Weight: 129.226
• Hs Code.: 2934999090
• Mol file: 28221-31-0.mol

Synonyms:4H-1,3-Thiazine,5,6-dihydro-2-ethyl;2-ethyl-5,6-dihydro-4H-[1,3]thiazine;5,6-Dihydro-2-ethyl-4H-1,3-thiazine;2-Aethyl-5,6-dihydro-4H-[1,3]thiazin;

Chemical Property of 2-Ethyl-5,6-dihydro-4H-1,3-thiazine

Chemical Property:

• Vapor Pressure: 1.12mmHg at 25°C
• Boiling Point: 182.1°Cat760mmHg
• PKA: 6.25±0.20(Predicted)
• Flash Point: 63.9°C
• PSA: 37.66000
• Density: 1.08g/cm³
• LogP: 1.36740

Purity/Quality:

99% ^*data from raw suppliers

2-ETHYL-5,6-DIHYDRO-4H-1,3-THIAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-5,6-dihydro-4H-1,3-thiazine

There total 4 articles about 2-Ethyl-5,6-dihydro-4H-1,3-thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

γ-hydroxy-propyl propionamide (10601-74-8) → 2-ethyl-5,6-dihydro-4H-[1,3]thiazine (28221-31-0)

Guidance literature:

With tetraphosphorus decasulfide; at 120 - 130 ℃; for 1.5h; suspension in mineral acid;

Reference yield:

N-(2-hydroxyethyl)propionamide (18266-55-2) → 2-ethyl-5,6-dihydro-4H-[1,3]thiazine (28221-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawesson's reagent / toluene / 1 h / Heating

2: 9.7 g / toluene / 1 h

With Lawessons reagent; In toluene;

DOI:10.1016/j.tet.2007.03.089

Reference yield:

N-(2-hydroxy-ethyl)-thiopropionamide (77706-73-1) + potassium carbonate (584-08-7) → 2-ethyl-5,6-dihydro-4H-[1,3]thiazine (28221-31-0)

Guidance literature:

In toluene; for 1h;

DOI:10.1016/j.tet.2007.03.089

upstream raw materials:

propionic acid

propan-1-ol-3-amine

γ-hydroxy-propyl propionamide

N-(2-hydroxy-ethyl)-thiopropionamide

Downstream raw materials:

3-methyl-1-(3-(8-methyl-6-oxo-7-phenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-4-phenyl-1H-pyrrole-2,5-dione

1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3-methyl-4-phenyl-1H-pyrrole-2,5-dione)

(Z)-3-(2,2-dichloro-2-phenylacetyl)-2-ethylidene-1,3-thiazinane