1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione
• CAS No.: 75500-00-4
• Molecular Formula: C₂₃H₂₄N₂O₂Si
• Molecular Weight: 388.541
• Mol file: 75500-00-4.mol

Synonyms:1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property of 1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione

There total 2 articles about 1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3-dibenzyl-5-bromopyrimidine-2,4(1H,3H)-dione (33242-55-6) + trimethylsilylacetylene (1066-54-2) → 1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione (75500-00-4)

Guidance literature:

1,3-dibenzyl-5-bromopyrimidine-2,4(1H,3H)-dione; trimethylsilylacetylene; With TPGS-750-M; triethylamine; In water; at 23 - 25 ℃; for 0.166667h; Inert atmosphere;

With (2S,3S)-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2-(2,4,6-triisopropylbenzyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; palladium diacetate; In water; toluene; at 45 ℃; for 30h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03621

Reference yield:

benzyl bromide (100-39-0) + 5-(trimethylsilylethynyl)uracil (83355-90-2) → 1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione (75500-00-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(01)83925-3

Reference yield:

1,3-dibenzyl-5-((trimethylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione (75500-00-4) → 1,3-Dibenzyl-5-trimethylsilanylethynyl-dihydro-pyrimidine-2,4-dione (75500-10-6)

Guidance literature:

With water; L-Selectride; Yield given. Multistep reaction; 1.) THF, dry ice-acetone bath, 5-10 min;

DOI:10.1016/S0040-4039(01)83925-3

upstream raw materials:

benzyl bromide

5-(trimethylsilylethynyl)uracil

1,3-dibenzyl-5-bromopyrimidine-2,4(1H,3H)-dione

trimethylsilylacetylene

Downstream raw materials:

1,3-Dibenzyl-5-trimethylsilanylethynyl-dihydro-pyrimidine-2,4-dione