7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid

Base Information

• Chemical Name: 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid
• CAS No.: 1397213-18-1
• Molecular Formula: C₂₁H₁₇N₃O₄
• Molecular Weight: 375.384

Synonyms:7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid

Chemical Property of 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid

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Technology Process of 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid

There total 3 articles about 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate (1397213-74-9) → 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid (1397213-18-1)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Reflux;

DOI:10.1002/cmdc.201200205

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid (1397213-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / tetrahydrofuran / 8 h / 20 °C

2: hydrogenchloride / ethanol; water / 2 h / Reflux

3: sodium hydroxide / methanol / 2 h / Reflux

With hydrogenchloride; sodium methylate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1002/cmdc.201200205

Reference yield:

methyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate (70311-75-0) → 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid (1397213-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 2 h / Reflux

2: sodium hydroxide / methanol / 2 h / Reflux

With hydrogenchloride; sodium hydroxide; In methanol; ethanol; water;

DOI:10.1002/cmdc.201200205

upstream raw materials:

methyl 7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate

1-(3,4-dimethoxyphenyl)ethanone

methyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate

Downstream raw materials:

(7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidin-5-yl)(4-(2-(furan-2-ylmethylamino)benzoyl)piperazin-1-yl)methanone

(7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidin-5-yl)(4-(2-(thiophen-2-ylmethylamino)benzoyl)piperazin-1-yl)methanone

(4-(2-(benzo[d][1,3]dioxol-5-ylmethylamino)benzoyl)piperazin-1-yl)(7-(3,4-dimethoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidin-5-yl)methanone

N-(6-fluorobenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide

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