methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

Base Information

Chemical Name:methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside
CAS No.:111651-52-6
Molecular Formula:C₃₅H₃₇NO₅
Molecular Weight:551.682
Hs Code.:

Synonyms:methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

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Chemical Property of methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

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Technology Process of methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

There total 3 articles about methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 100-39-0
benzyl bromide

: 111651-51-5
methyl 2-acetamido-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

: 111651-52-6
methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;
DOI:10.1246/bcsj.60.1529

Reference yield:

: 25541-56-4
methyl 2-acetylamino-2,3-dideoxy-α-D-ribo-hexopyranoside

: 111651-52-6
methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1: 12.6 g / 4-dimethylaminopyridine, triethylamine / pyridine / 60 °C

2: 99 percent / 60 percent sodium hydride, tetrabutylammonium iodide / dimethylformamide / 1.5 h / Ambient temperature

3: 85 percent / p-toluenesulfonic acid / methanol / 1 h

4: 1.) pyridine, phosphoric acid, dicyclohexylcarbodiimide; 2.) oxalic acid / 1.) DMSO, benzene, 2 h, rt; 2.) methanol

5: 1 M sodium methoxide / methanol

With pyridine; dmap; phosphoric acid; sodium methylate; oxalic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.60.1529

Reference yield:

: 76-83-5
trityl chloride

: 111651-52-6
methyl 2-acetamido-4-O-benzyl-2,3-dideoxy-6-O-trityl-α-D-ribo-hexopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 12.6 g / 4-dimethylaminopyridine, triethylamine / pyridine / 60 °C

2: 99 percent / 60 percent sodium hydride, tetrabutylammonium iodide / dimethylformamide / 1.5 h / Ambient temperature

With dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; In pyridine; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.60.1529