Ethyl 2-bromothiazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 2-bromothiazole-4-carboxylate
• CAS No.: 100367-77-9
• Molecular Formula: C6H6BrNO2S
• Molecular Weight: 236.089
• Hs Code.: 29341000
• Mol file: 100367-77-9.mol

Synonyms:2-Bromothiazole-4-carboxylic acid ethyl ester;2-Bromo-thiazole-4-carboxylic acid ethyl ester;Ethyl 2-bromo-1,3-thiazole-4-carboxylate;

Chemical Property of Ethyl 2-bromothiazole-4-carboxylate

Chemical Property:

• Appearance/Colour: white crystalline power
• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 48-52 °C
• Refractive Index: 1.549
• Boiling Point: 277.6 °C at 760 mmHg
• PKA: -1.50±0.10(Predicted)
• Flash Point: 121.7 °C
• PSA: 67.43000
• Density: 1.654 g/cm³
• LogP: 2.08230
• Storage Temp.: Keep Cold
• Sensitive.: Moisture & Light Sensitive
• Solubility.: soluble in Methanol

Purity/Quality:

98% HPLC ^*data from raw suppliers

Ethyl 2-bromothiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-bromothiazole-4-carboxylate

There total 11 articles about Ethyl 2-bromothiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-aminothiazole-4-carboxylate (5398-36-7) → ethyl 2-bromothiazole-4-carboxylate (100367-77-9)

Guidance literature:

With tert.-butylnitrite; copper(ll) bromide; In acetonitrile;

DOI:10.1134/S1070363217120039

Reference yield: 75.0%

→ ethyl 2-bromothiazole-4-carboxylate (100367-77-9)

Guidance literature:

Reference yield: 63.5%

→ ethyl 2-bromothiazole-4-carboxylate (100367-77-9) + ethyl 2-imidazol-1-yl-thiazole-4-carboxylate (256420-32-3)

Guidance literature:

upstream raw materials:

2-aminothiazole-4-carboxylate

2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide

ethyl Bromopyruvate

thiourea

Downstream raw materials:

Thiazole-4-carboxylic acid

ethyl thiazole-4-carboxylate

2-bromo-thiazole-4-carboxylic acid methyl ester

(2-bromo-1,3-thiazol-4-yl)methanol

Refernces

• 1、 Ung, Alison T.,Pyne, Stephen G.. "Asymmetric synthesis of (1R,2S,3R)-2-acetyl-4-(1,2,3,4- tetrahydroxybutyl)thiazole". . p. 1395 - 1407. Retrieved 1998.
• 2、 Parker, Jeremy S.,McCormick, Marc,Anderson, David W.,Maltman, Beatrice A.,Gingipalli, Lakshmaiah,Toader, Dorin. "The Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload". . p. 1602 - 1609. Retrieved 2017.
• 3、 -. "1-(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1-YL)-ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION". Page/Page column 47; 48. . Retrieved 2021/05/21.
• 4、 -. "NOVEL SULFILIMINES OR SULFOXIMINES CONTAINING FUNGICIDAL HETEROCYCLIC COMPOUNDS". Page/Page column 65-66. . Retrieved 2021/05/21.