ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE
• CAS No.: 127942-30-7
• Molecular Formula: BrH*C₆H₈N₂O₂S
• Molecular Weight: 253.12
• Hs Code.: 2934100090
• Mol file: 127942-30-7.mol

Synonyms:2-Aminothiazole-4-carboxylic acid ethyl ester monohydrobromide;ETHYL-2-AMINOTHIAZOLE-4-CARBOXYLIC ACID;ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE hcl;2-Aminothiazole-4-carboxylic acid ethyl ester hydrobromide;4-THIAZOLECARBOXYLIC ACID,2-AMINO-,ETHYL ESTER;ethyl 2-aMinothiazol-4-carboxylate HBr;

Chemical Property of ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE

Chemical Property:

• PSA: 93.45000
• LogP: 2.44130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-Aminothiazole-4-carboxylateHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE

There total 5 articles about ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl Bromopyruvate (70-23-5) + thiourea (17356-08-0) → 2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide (127942-30-7)

Guidance literature:

In ethyl acetate; at 60 - 110 ℃; Cooling;

Reference yield: 85.0%

ethyl Bromopyruvate (70-23-5) → 2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide (127942-30-7)

Guidance literature:

With thiourea;

Reference yield:

ethyl bromopyruvate (1378831-76-5) + thiourea (17356-08-0) → 2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide (127942-30-7)

Guidance literature:

In acetone; at 100 ℃; for 0.75h;

upstream raw materials:

ethyl Bromopyruvate

thiourea

ethyl bromopyruvate

thiourea

Downstream raw materials:

ethyl 2-phenoxycarbonyl-amino-thiazole-4-carboxylate

Refernces

• 1、 -. "INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING ALPHA-V-BETA-3". Page/Page column 40. . Retrieved 2013/08/15.
• 2、 Delgado, Oscar,Martin Mueller,Bach, Thorsten. "Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A". experimental part. p. 2322 - 2339. Retrieved 2009/04/10.