methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate

Base Information

• Chemical Name: methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate
• CAS No.: 1412449-37-6
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.402
• Mol file: 1412449-37-6.mol

Synonyms:methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate

Chemical Property of methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate

There total 5 articles about methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2-{5-methoxy-2-methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]-1H-indol-3-yl}acetate + methyl iodide (74-88-4) → methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate (1412449-37-6)

Guidance literature:

With C₂₁H₃₀ClNPPd; potassium tert-butylate; In tert-Amyl alcohol; at 65 ℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.9b00025

Reference yield: 82.0%

indomethacin methyl ester (1601-18-9) → methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate (1412449-37-6)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; nickel(II) bromide 2-methoxyethyl ether complex; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; N,N-dimethyl acetamide; for 48h; Glovebox; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1039/d0ob01610a

Reference yield: 80.0%

C19H14BO2(1-)*Li(1+) + indomethacin methyl ester (1601-18-9) → methyl 2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetate (1412449-37-6) + 8,9-dioxa-8a-borabenzo[fg]tetracene

Guidance literature:

With nickel(II) bromide diethylene glycol dimethyl ether; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; for 24h; Inert atmosphere; Irradiation; Sealed tube; Glovebox;

DOI:10.1021/jacs.0c04456

upstream raw materials:

4-methyl-benzoyl chloride

methyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate

methyl iodide

indomethacin methyl ester

Downstream raw materials:

2-(5-methoxy-2-methyl-1-(4-methylbenzoyl)-1H-indol-3-yl)acetic acid