Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate

Base Information

Chemical Name:Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate
CAS No.:129150-62-5
Molecular Formula:C₁₈H₁₈O₅
Molecular Weight:314.338
Hs Code.:
DSSTox Substance ID:DTXSID501214041

Synonyms:Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate;DTXSID501214041;129150-62-5

Suppliers and Price of Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:314.11542367
Heavy Atom Count:23
Complexity:376

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCC(=O)OC)OC2=CC=C(C=C2)C=O

Technology Process of Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate

There total 4 articles about Methyl 3-(4-formylphenoxy)-4-methoxybenzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-59-0
isovanillin

: 129150-62-5
3-[3-(4-formylphenoxy)-4-methoxyphenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / CH₂Cl₂ / 22 h

2: 91 percent / HCO₂NH₄ / Pd/C / methanol / 3 h / Heating

3: 68 percent / Et₃N; Cu(OAc)2; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

With copper diacetate; 4 A molecular sieve; ammonium formate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; 1: Wittig reaction;
DOI:10.1039/b513515j

Reference yield:

: 16980-82-8
3-(3-hydroxy-4-methoxyphenyl)-acrylic acid methyl ester

: 129150-62-5
3-[3-(4-formylphenoxy)-4-methoxyphenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / HCO₂NH₄ / Pd/C / methanol / 3 h / Heating

2: 68 percent / Et₃N; Cu(OAc)2; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

With copper diacetate; 4 A molecular sieve; ammonium formate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/b513515j

Reference yield:

: 10602-01-4
p-bromobenzaldehyde 1,3-dioxolane

: 129150-62-5
3-[3-(4-formylphenoxy)-4-methoxyphenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

1.2: tetrahydrofuran; hexane / 20 °C

1.3: 64 percent / aq. HCl / hexane; tetrahydrofuran / 2 h / 20 °C

2.1: 68 percent / Et₃N; Cu(OAc)2; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

With n-butyllithium; copper diacetate; 4 A molecular sieve; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b513515j