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16980-82-8

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16980-82-8 Usage

Chemical Properties

White Solid

Uses

Methyl 3-(3-Hydroxy-4-Methoxyphenyl)acrylate is a useful synthetic intermediate in the preparation of pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 16980-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,9,8 and 0 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 16980-82:
(7*1)+(6*6)+(5*9)+(4*8)+(3*0)+(2*8)+(1*2)=138
138 % 10 = 8
So 16980-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H12O4/c1-14-10-5-3-8(7-9(10)12)4-6-11(13)15-2/h3-7,12H,1-2H3/b6-4+

16980-82-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl (E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoate

1.2 Other means of identification

Product number -
Other names Methyl isoferulate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16980-82-8 SDS

16980-82-8Relevant articles and documents

Design, synthesis and antitumor evaluation of novel celastrol derivatives

Xu, Manyi,Li, Na,Zhao, Zihao,Shi, Zhixian,Sun, Jianbo,Chen, Li

, p. 265 - 276 (2019/05/04)

On the basis of the hybridization strategy of natural products, a total of 32 novel celastrol hybrids were designed, synthesized and evaluated for their antitumor activities. Most of these derivatives exihibited significant antiproliferative activities compared to celastrol, among which compound 29 displayed the strongest inhibitory capability [IC50 = 0.15 ± 0.03 μM (A549),0.17 ± 0.03 μM (MCF-7), 0.26 ± 0.02 μM (HepG2)], which exhibited equal or superior anti-cancer activities in comparison to 2-cyano-3,12-dioxoolean-1,9 (11)-dien-28-oic acid methyl ester (CDDO-Me). The mechanism of pharmacological research indicated that 29 possessed the ability to disrupt Hsp90-Cdc37 complex which was stronger than celastrol. Meanwhile, compound 29 could induce abnormal regulation of clients (p-Akt and Cdk4) of Hsp90 and cell cycle arrest at G0/G1 phase in a concentration-dependent manner. In addition, compound 29 could also induce cell apoptosis through the death receptor pathway on A549 cells. Taken together, our results demonstrated that 29 might be a promising novel candidate for further druggability research.

Gram-scale enantioselective formal synthesis of morphine through an orth?para oxidative phenolic coupling strategy

Tissot, Matthieu,Phipps, Robert J.,Lucas, Catherine,Leon, Rafael M.,Pace, Robert D.M.,Ngouansavanh, Tifelle,Gaunt, Matthew J.

supporting information, p. 13498 - 13501 (2015/02/19)

A gram-scale catalytic enantioselective formal synthesis of morphine is described. The key steps of the synthesis involve an orth?para oxidative phenolic coupling and a highly diastereoselective "desymmetrization" of the resulting cyclohexadienone that generates three of the four morphinan ring junction stereocenters in one step. The stereochemistry is controlled from a single carbinol center installed through catalytic enantioselective hydrogenation. These transformations enabled the preparation of large quantities of key intermediates and could support a practical and scalable synthesis of morphine and related derivatives.

A new approach to combretastatin D2

Cousin, David,Mann, John,Nieuwenhuyzen, Mark,Van Den Berg, Hendrik

, p. 54 - 62 (2007/10/03)

A concise and convergent route to combretastatin D2 is described together with some preliminary biological data. The Royal Society of Chemistry 2006.

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