4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

Base Information

Chemical Name:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester
CAS No.:1455093-41-0
Molecular Formula:C₂₄H₂₃N₃O₅
Molecular Weight:433.464
Hs Code.:

Synonyms:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

Chemical Property:

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Technology Process of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

There total 2 articles about 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1455091-14-1
4-amino-2,2-dimethylbutyric acid methyl ester trifluoroacetic acid salt

: 1455091-23-2
1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

: 1455093-41-0
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

Guidance literature:: With sodium methylate; In methanol; pH=8; Reflux;

Reference yield:

: 1455091-12-9
2,2-dimethyl-4-(tritylamino)butyric acid methyl ester

: 1455093-41-0
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 20 °C

2: sodium methylate / methanol / pH 8 / Reflux

With sodium methylate; In methanol; dichloromethane;