4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

Base Information

Chemical Name:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid
CAS No.:1455088-72-8
Molecular Formula:C₂₃H₂₁N₃O₅
Molecular Weight:419.437
Hs Code.:

Synonyms:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

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Chemical Property of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

Chemical Property:

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Technology Process of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

There total 3 articles about 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1455093-41-0
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid methyl ester

: 1455088-72-8
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 1455091-14-1
4-amino-2,2-dimethylbutyric acid methyl ester trifluoroacetic acid salt

: 1455088-72-8
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / pH 8 / Reflux

2: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

With sodium methylate; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1455091-12-9
2,2-dimethyl-4-(tritylamino)butyric acid methyl ester

: 1455088-72-8
4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 2 h / 20 °C

2: sodium methylate / methanol / pH 8 / Reflux

3: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

With sodium methylate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;