benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Base Information

Chemical Name:benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS No.:1621482-50-5
Molecular Formula:C₁₆H₂₀N₄O₄
Molecular Weight:332.359
Hs Code.:

Synonyms:benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Chemical Property of benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Technology Process of benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

There total 7 articles about benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1621482-49-2
benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1621482-50-5
benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: With hydrazine hydrate; In ethanol; at 90 ℃; for 2h;

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1621482-50-5
benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / water / 1 h / 0 °C

1.2: 25 h / 0 - 20 °C

2.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C

3.1: triethylamine / dichloromethane / 0.75 h / -40 °C

3.2: 16 h / -40 - 20 °C

4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 0 °C

5.1: caesium carbonate / acetonitrile / 16 h / 20 °C

6.1: hydrazine hydrate / ethanol / 2 h / 90 °C

With ammonium cerium (IV) nitrate; oxalyl dichloride; sodium carbonate; caesium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1621482-50-5
benzyl 2-(2-hydrazinyl-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / dichloromethane / 2 h / 0 °C

2.1: triethylamine / dichloromethane / 0.75 h / -40 °C

2.2: 16 h / -40 - 20 °C

3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 0 °C

4.1: caesium carbonate / acetonitrile / 16 h / 20 °C

5.1: hydrazine hydrate / ethanol / 2 h / 90 °C

With ammonium cerium (IV) nitrate; oxalyl dichloride; caesium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; water; acetonitrile;