benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Base Information

Chemical Name:benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS No.:1621482-49-2
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Chemical Property of benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

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Technology Process of benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

There total 6 articles about benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

: 914389-34-7
benzyl 2-(4-methoxybenzyl)-1-oxo-2,5-diazaspiro[3.4]-octane-5-carboxylate

: 105-36-2
ethyl bromoacetate

: 1621482-49-2
benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; for 16h; Time;

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1621482-49-2
benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / water / 1 h

1.2: 25 h / 0 - 20 °C

2.1: thionyl chloride / dichloromethane / 2 h / 0 °C

3.1: boron trifluoride diethyl etherate; triethylamine / dichloromethane / 16.75 h / -40 - 20 °C

4.1: ammonium cerium (IV) nitrate; water / acetonitrile / 1 h / 0 - 20 °C

5.1: caesium carbonate / acetonitrile / 16 h / 20 °C

With thionyl chloride; ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; water; sodium carbonate; caesium carbonate; triethylamine; In dichloromethane; water; acetonitrile;

Reference yield:

: 61350-60-5,61350-62-7,89705-40-8,106709-50-6
(S)-benzyloxycarbonyl-proline acid chloride

: 1621482-49-2
benzyl 2-(2-ethoxy-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate; triethylamine / dichloromethane / 16.75 h / -40 - 20 °C

2: ammonium cerium (IV) nitrate; water / acetonitrile / 1 h / 0 - 20 °C

3: caesium carbonate / acetonitrile / 16 h / 20 °C

With ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; water; caesium carbonate; triethylamine; In dichloromethane; acetonitrile;