4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone

Base Information

• Chemical Name: 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone
• CAS No.: 6546-65-2
• Molecular Formula: C₄₃H₄₆O₂₂
• Molecular Weight: 914.825
• Mol file: 6546-65-2.mol

Synonyms:4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone

Chemical Property of 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone

There total 2 articles about 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + rhoifolin (17306-46-6) → 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone (6546-65-2)

Guidance literature:

With pyridine;

Reference yield:

naringin (10236-47-2) → 4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone (6546-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; pyridine / pyridine / 6 h / 95 °C

2: pyridine / 6 h / 95 °C

With pyridine; iodine; In pyridine;

DOI:10.1016/j.molcatb.2016.03.001

Reference yield: 98.0%

4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone (6546-65-2) → 5-acetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]-4'-hydroxyflavone

Guidance literature:

With Candida antarctica lipase B (Novozymes,Novozym 435); isopropyl alcohol; In tetrahydrofuran; at 22 ℃; for 72h; Reagent/catalyst; regioselective reaction; Enzymatic reaction;

DOI:10.1016/j.molcatb.2016.03.001

upstream raw materials:

acetic anhydride

rhoifolin

naringin

Downstream raw materials:

3-bromo-2-methoxyoctacetylnaringin

1,2,3,4-tetra-O-acetyl-L-rhamnopyranose

apigenin 7-O-β-glucoside hexaacetate