17306-46-6

Basic information

• Product Name: RHOIFOLIN
• Synonyms: APIGENIN-7-NEOHESPERIDOSIDE;APIGENIN 7-O-NEOHESPERIDOSIDE;APIGENIN-7-RHAMNOGLUCOSIDE;RHOIFOLIN;7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one;7-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5- hydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one;APIGENIN-7-NEOHESPERIDOSIDE hplc;RHOIFOLIN WITH HPLC
• CAS NO: 17306-46-6
• Molecular Formula: C₂₇H₃₀O₁₄
• Molecular Weight: 578.52
• EINECS: 241-335-4
• Product Categories: Tri-substituted Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;Inhibitors
• Mol File: 17306-46-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 250-265 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 916.5 °C at 760 mmHg
• Flash Point: 305.4 °C
• Appearance: /
• Density: 1.69 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: 0-6°C
• PKA: 6.11±0.40(Predicted)
• CAS DataBase Reference: RHOIFOLIN(CAS DataBase Reference)
• NIST Chemistry Reference: RHOIFOLIN(17306-46-6)
• EPA Substance Registry System: RHOIFOLIN(17306-46-6)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 17306-46-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 17306-46-6 differently. You can refer to the following data:
1. antiinflammatory
2. Rhoifolin is a flavone, a type of flavonoid, a new natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea. Rhoifolin has been shown to be an apigenin-7-rhamnoglucosi de. Rhoifolin apparently is identical with the apigenin-7-rhamnoglucoside obtained by the bromination and dehydrobromination of Naringin (N378980).
3. Rhoifolin is a flavone, a type of flavonoid, a new natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea. Rhoifolin has been shown to be an apigenin-7-rhamnoglucoside. Rhoifolin apparently is identical with the apigenin-7-rhamnoglucoside obtained by the bromination and dehydrobromination of Naringin (N378980).

InChI:InChI=1/C27H30O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-8,10,18,20-30,32-36H,9H2,1H3/t10-,18+,20-,21+,22+,23?,24+,25+,26-,27+/m0/s1

Upstream product

• 10236-47-2 naringin 

Downstream Products

• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 578-74-5 apigenin 7-O-glucoside 
• 5128-44-9 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 13698-23-2 apigenin 4',5-dimethyl ether 
• 2798-20-1 gardenin B 
• 481-53-8 tangeritin 
• 73213-66-8 7-hydroxy-5,6,8,4′-tetramethoxyflavone 
• 50439-46-8 5-hydroxy-3,6,7,8,4′-pentamethoxyflavone 
• 34170-18-8 3,5,6,7,8,4′-hexamethoxyflavone 
• 50461-91-1 3-hydroxy-5,6,7,8,4′-pentamethoxyflavone 
• 890661-78-6 3'-nitro-3-(3'',4'',5''-trimethoxyphenyl)acacetin 7-benzyl ether 
• 890661-77-5 3'-nitro-3-(3'',4'',5''-trimethoxyphenyl)acacetin 7-methyl ether 
• 890661-87-7 3-bromo-3'-nitroacacetin 7-benzyl ether 

Relevant articles and documents

Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin

Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as?the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1–8) were synthesised from naringin. The bioactivity evaluation revealed that most of them exhibited moderate or potent acetylcholinesterase (AChE) inhibitory activity. Among them, compound 7 (IC50 for AChE?=?0.82?±?0.08?μmol?L?1, IC50 for BuChE?=?46.30?±?3.26?μmol?L?1) showed a potent activity and high selectivity compared with the positive control Rivastigmine (IC50 for AChE?=?10.54?±?0.86?μmol?L?1, IC50 for BuChE?=?0.26?±?0.08?μmol?L?1). The kinetic study suggested that compound 7 bind to AChE with mix-type inhibitory profile. Molecular docking study revealed that compound 7 could combine both catalytic active site (CAS) and peripheral active site (PAS) of AChE with four points (Trp84, Trp279, Tyr70 and Phe330), while it could bind with BuChE via only His 20.

A simple method for the conversion of flavanones into flavones

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The invention relates to a raw material to synthesize the tin setose thistle glucoside naringin method (by machine translation)

The invention discloses a to naringin as raw material synthetic tin setose thistle glucoside method, comprises the following steps: S1, synthesis of wild lacquer tree glucoside; S2, compound 5, 7 - dihydroxy - 2 - (4 - methoxyphenyl) - 4 H - chromen - 4 - one synthesis; acetoxy methyl) - 6 - ((5 - hydroxy - 2 - (4 - methoxyphenyl) - 4 - oxo - 4 H - chromen - 7 - yl) oxy) tetrahydro - 2 H - pyran - 3, 4, 5 - [...] acetate synthesis; S4, compound 5 - hydroxy - 2 - (4 - methoxyphenyl) - 7 - (( (2 S, 3 R, 4 S, 5 S, 6 R) - 3, 4, 5 - trihydroxy - 6 - (hydroxymethyl) tetrahydro - 2 H - pyran - 2 - Kiki) oxy) - 4 H - benzopyran - 4 - one synthesis. The invention to naringin as raw materials, by oxidation, methylation, hydrolysis reaction to synthesize tian jigan. (by machine translation)