5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine

Base Information

• Chemical Name: 5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine
• CAS No.: 1256914-47-2
• Molecular Formula: C₈H₁₁N*C₁₁H₁₇NO₄
• Molecular Weight: 348.442
• Mol file: 1256914-47-2.mol

Synonyms:5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine

Chemical Property of 5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine

There total 1 articles about 5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) + syn-N-(t-butoxycarbonyl)-5-carboxy-2-azabicyclo[2.1.1]hexane (615575-74-1) → (-)-(1S,4R,5R)-5-syn-carboxy-N-Boc-2-azabicyclo[2.1.1]hexane (1256914-30-3,615575-74-1) + 5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine (1256914-47-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 6.5h;

DOI:10.1021/ol1022917

Reference yield:

5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine (1256914-47-2) → (1S,4R,5R)-(-)-5-syn-(S)-(1-phenylethylcarbamoyl)-N-Boc-2-azabicyclo[2.1.1]hexane (1256914-37-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/ol1022917

Reference yield:

5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine (1256914-47-2) → (-)-(1S,4R,5R)-5-syn-carboxy-N-Boc-2-azabicyclo[2.1.1]hexane (1256914-30-3,615575-74-1)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; pH=2.5;

DOI:10.1021/ol1022917

upstream raw materials:

(S)-1-phenyl-ethylamine

syn-N-(t-butoxycarbonyl)-5-carboxy-2-azabicyclo[2.1.1]hexane

Downstream raw materials:

(-)-(1S,4R,5R)-5-syn-carboxy-N-Boc-2-azabicyclo[2.1.1]hexane

(1S,4R,5R)-(-)-5-syn-(S)-(1-phenylethylcarbamoyl)-N-Boc-2-azabicyclo[2.1.1]hexane