11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

Base Information

Chemical Name:11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione
CAS No.:1325226-74-1
Molecular Formula:C₂₃H₂₅BrN₂O₄
Molecular Weight:473.366
Hs Code.:

Synonyms:11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

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Chemical Property of 11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

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Technology Process of 11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

There total 2 articles about 11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1325226-73-0
phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1325226-74-1
11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 75 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol201739u

Reference yield:

: 17680-54-5
7-bromo-3,4-dihydroisoquinoline

: 1325226-74-1
11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / 22 h / -78 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 75 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol201739u

Reference yield: 72.0%

: 110-91-8,99108-56-2
morpholine

: 1325226-74-1
11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

: 1325226-75-2
3-(3,4-dimethoxyphenethyl)-11-morpholino-1,3,4,7,8,12b-hexahydro[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol201739u