phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Base Information

Chemical Name:phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate
CAS No.:1325226-73-0
Molecular Formula:C₁₉H₁₇BrClNO₃
Molecular Weight:422.706
Hs Code.:

Synonyms:phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

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Chemical Property of phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

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Technology Process of phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

There total 1 articles about phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 17680-54-5
7-bromo-3,4-dihydroisoquinoline

: 111061-31-5
1-phenoxy-1-trimethylsilyloxyethene

: 79-04-9
chloroacetyl chloride

: 1325226-73-0
phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; at -78 ℃; for 22h; Inert atmosphere;
DOI:10.1021/ol201739u

Reference yield: 69.0%

: 1325226-73-0
phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1325226-74-1
11-bromo-3-(3,4-dimethoxyphenethyl)-1,3,4,7,8,12b-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 75 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol201739u

Reference yield:

: 1325226-73-0
phenyl 2-(7-bromo-2-(2-chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1325226-75-2
3-(3,4-dimethoxyphenethyl)-11-morpholino-1,3,4,7,8,12b-hexahydro[1,4]diazepino[7,1-a]isoquinoline-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 75 °C / Inert atmosphere

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 2 h / 80 °C / Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In toluene; acetonitrile; 2: Buchwald-Hartwig cross-coupling;
DOI:10.1021/ol201739u