4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one

Base Information

• Chemical Name: 4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one
• CAS No.: 130558-53-1
• Molecular Formula: C₁₃H₁₀ClN₃O₂
• Molecular Weight: 275.694

Synonyms:4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one

Chemical Property of 4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one

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Technology Process of 4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one

There total 1 articles about 4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 2-chloro-2-phenylacetate (10606-73-2,99531-04-1,116836-53-4,4773-33-5) + 4-amino-6-chloro-5-hydroxy-2-methylpyrimidine (38953-43-4) → 4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one (130558-53-1)

Guidance literature:

With triethylamine; In ethanol; for 7h; Heating;

DOI:10.1016/0223-5234(90)90117-L

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + 4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one (130558-53-1) → 2-Methyl-4-morpholin-4-yl-6-phenyl-8H-pyrimido[5,4-b][1,4]oxazin-7-one (130558-70-2)

Guidance literature:

In butan-1-ol; Heating;

DOI:10.1016/0223-5234(90)90117-L

Reference yield: 74.0%

4-chloro-2-methyl-6-phenyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one (130558-53-1) + chloroacetic acid ethyl ester (105-39-5) → (4-Chloro-2-methyl-7-oxo-6-phenyl-6,7-dihydro-pyrimido[5,4-b][1,4]oxazin-8-yl)-acetic acid ethyl ester (130558-67-7)

Guidance literature:

With potassium carbonate; In butanone; for 8h; Heating;

DOI:10.1016/0223-5234(90)90117-L

upstream raw materials:

ethyl 2-chloro-2-phenylacetate

4-amino-6-chloro-5-hydroxy-2-methylpyrimidine

Downstream raw materials:

2-Methyl-4-morpholin-4-yl-6-phenyl-8H-pyrimido[5,4-b][1,4]oxazin-7-one

2-Methyl-4-(2-morpholin-4-yl-ethylamino)-6-phenyl-8H-pyrimido[5,4-b][1,4]oxazin-7-one

4-(2-Hydroxy-ethylamino)-2-methyl-6-phenyl-8H-pyrimido[5,4-b][1,4]oxazin-7-one

(4-Chloro-2-methyl-7-oxo-6-phenyl-6,7-dihydro-pyrimido[5,4-b][1,4]oxazin-8-yl)-acetic acid ethyl ester

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