4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

Base Information

Chemical Name:4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide
CAS No.:1227865-12-4
Molecular Formula:C₂₅H₂₇ClN₆O₂
Molecular Weight:478.981
Hs Code.:

Synonyms:4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

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Technology Process of 4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

There total 2 articles about 4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1227864-55-2
4-(benzylamino)-6-({[4-piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 541-88-8
Chloroacetic anhydride

: 1227865-12-4
4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

Guidance literature:: 4-(benzylamino)-6-({[4-piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide; Chloroacetic anhydride; In dichloromethane; at 20 ℃; for 0.333333h;

With ammonium hydroxide; In dichloromethane; water;

Reference yield:

: 1227864-42-7
4-(benzylamino)-6-({4-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

: 1227865-12-4
4-(benzylamino)-6-({4-[4-(chloroacetyl)piperazin-1-yl]phenyl}amino)pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; barium(II) hydroxide / methanol / 0.5 h / 50 °C

2: dichloromethane / 0.33 h / 20 °C

With water; barium(II) hydroxide; In methanol; dichloromethane;