3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

Base Information

Chemical Name:3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one
CAS No.:1042131-31-6
Molecular Formula:C₃₄H₂₆N₂O₃
Molecular Weight:510.592
Hs Code.:

Synonyms:3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

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Chemical Property of 3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

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Technology Process of 3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

There total 7 articles about 3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1042131-30-5
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

: 1042131-31-6
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

Guidance literature:: With TBAF on silica gel; In tetrahydrofuran; for 2h;

Reference yield:

: 3096-56-8
2-bromofluoren-9-one

: 1042131-31-6
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / acetonitrile

2.1: isopropylmagnesium chloride / tetrahydrofuran / -15 - 20 °C

2.2: -80 °C

3.1: TBAF on silica gel / tetrahydrofuran / 2 h

With TBAF on silica gel; isopropylmagnesium chloride; cesium fluoride; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1133-80-8
2-bromo-9H-fluorene

: 1042131-31-6
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-fluorene-9-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; tetra(n-butyl)ammonium hydroxide; oxygen / methanol / 60 h

2.1: cesium fluoride / acetonitrile

3.1: isopropylmagnesium chloride / tetrahydrofuran / -15 - 20 °C

3.2: -80 °C

4.1: TBAF on silica gel / tetrahydrofuran / 2 h

With pyridine; TBAF on silica gel; tetra(n-butyl)ammonium hydroxide; isopropylmagnesium chloride; oxygen; cesium fluoride; In tetrahydrofuran; methanol; acetonitrile;