3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

Base Information

Chemical Name:3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile
CAS No.:1042131-30-5
Molecular Formula:C₃₈H₃₅N₃O₃Si
Molecular Weight:609.8
Hs Code.:

Synonyms:3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

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Chemical Property of 3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

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Technology Process of 3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

There total 6 articles about 3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 927201-97-6
4-(4-isopropyl-phenyl)-6-propargyloxy-quinazoline-2-carbaldehyde

: 1042131-29-2
2-bromo-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

: 1042131-30-5
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

Guidance literature:: 2-bromo-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile; With isopropylmagnesium chloride; In tetrahydrofuran; at -15 - 20 ℃;

4-(4-isopropyl-phenyl)-6-propargyloxy-quinazoline-2-carbaldehyde; In tetrahydrofuran; at -80 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1133-80-8
2-bromo-9H-fluorene

: 1042131-30-5
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; tetra(n-butyl)ammonium hydroxide; oxygen / methanol / 60 h

2.1: cesium fluoride / acetonitrile

3.1: isopropylmagnesium chloride / tetrahydrofuran / -15 - 20 °C

3.2: -80 °C

With pyridine; tetra(n-butyl)ammonium hydroxide; isopropylmagnesium chloride; oxygen; cesium fluoride; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 3096-56-8
2-bromofluoren-9-one

: 1042131-30-5
3-{hydroxy-[4-(4-isopropyl-phenyl)-6-propargyloxy-quinazolin-2-yl]-methyl}-9-trimethylsilanyloxy-9H-fluorene-9-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: cesium fluoride / acetonitrile

2.1: isopropylmagnesium chloride / tetrahydrofuran / -15 - 20 °C

2.2: -80 °C

With isopropylmagnesium chloride; cesium fluoride; In tetrahydrofuran; acetonitrile;