(2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

Base Information

• Chemical Name: (2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine
• CAS No.: 853305-86-9
• Molecular Formula: C₂₅H₂₇F₇N₂O₂
• Molecular Weight: 520.49

Synonyms:(2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

Chemical Property of (2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

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Technology Process of (2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine

There total 1 articles about (2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4S)-2-(4-fluoro-2-methyl)phenyl-4-hydroxypiperidine (629956-92-9) + C17H18F6N3O(1+)*I(1-) → (2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine (853305-86-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 70 ℃; for 16h;

Reference yield:

(2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine (853305-86-9) + carbon tetrabromide (558-13-4) → (2R,4R)-4-bromo-1-[N-{1-(3,5-difluorophenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)piperidine (853306-03-3)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

(2R,4S)-1-[N-{1-(3,5-bistrifluoromethylphenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)-4-hydroxypiperidine (853305-86-9) + 1,1'-carbonyldiimidazole (530-62-1) → C29H29F7N4O3

Guidance literature:

In tetrahydrofuran; for 2h; Heating / reflux;

upstream raw materials:

(2R,4S)-2-(4-fluoro-2-methyl)phenyl-4-hydroxypiperidine

Downstream raw materials:

(2R,4R)-4-bromo-1-[N-{1-(3,5-difluorophenyl-1-methyl)ethyl}-N-methyl]aminocarbonyl-2-(4-fluoro-2-methylphenyl)piperidine

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