6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Base Information

Chemical Name:6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester
CAS No.:84969-50-6
Molecular Formula:C₃₁H₄₂N₄O₈S
Molecular Weight:630.762
Hs Code.:

Synonyms:6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Suppliers and Price of 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

There total 4 articles about 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 84969-49-3
6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid

: 84969-50-6
6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 - 4 deg C, 2 h, 2.) room temperature;
DOI:10.1002/recl.19821011206

Reference yield:

: 40290-63-9
Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine

: 84969-50-6
6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / aq. NAOh / dioxane

2: 89 percent / N-ethylmorpholine, HOBt, DCC / dimethylformamide / 1.) 2 h, 0 deg C, 2.) room temperature

3: 91 percent / 2 N NaOH / dioxane; H₂O / 0.75 h

4: 62 percent / DCC / dimethylformamide / 1.) 0 - 4 deg C, 2 h, 2.) room temperature

With N-ethylmorpholine;; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/recl.19821011206

Reference yield:

: 61543-56-4
boc-Phe-Met-OH

: 84969-50-6
6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methylsulfanyl-butyrylamino]-hexanoic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / N-ethylmorpholine, HOBt, DCC / dimethylformamide / 1.) 2 h, 0 deg C, 2.) room temperature

2: 91 percent / 2 N NaOH / dioxane; H₂O / 0.75 h

3: 62 percent / DCC / dimethylformamide / 1.) 0 - 4 deg C, 2 h, 2.) room temperature

With N-ethylmorpholine;; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/recl.19821011206