benzyl 2-hydroxy-3,3-dimethylbutanoate

Base Information

Chemical Name:benzyl 2-hydroxy-3,3-dimethylbutanoate
CAS No.:300854-35-7
Molecular Formula:C₁₃H₁₈O₃
Molecular Weight:222.284
Hs Code.:

Synonyms:benzyl 2-hydroxy-3,3-dimethylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 2-hydroxy-3,3-dimethylbutanoate

Chemical Property:

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Technology Process of benzyl 2-hydroxy-3,3-dimethylbutanoate

There total 1 articles about benzyl 2-hydroxy-3,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 21641-92-9,851866-86-9
(S)-2-hydroxy-3,3-dimethylbutanoic acid

: 300854-35-7
benzyl 2-hydroxy-3,3-dimethylbutanoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/j.bmcl.2004.02.080

Reference yield:

: 108-48-5
2,6-dimethylpyridine

: 300854-35-7
benzyl 2-hydroxy-3,3-dimethylbutanoate

: 3.3-dimethyl-2-(S)-(trifluoromethanesulfonyl)butyric acid benzyl ester

Guidance literature:: In dichloromethane; water;

Reference yield:

: 300854-35-7
benzyl 2-hydroxy-3,3-dimethylbutanoate

: 711028-26-1
(E)-(3S,10R,16S)-3-tert-Butyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂

2.1: H₂ / Pd/C / methanol

3.1: 69 percent / 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂

4.1: TFA / CH₂Cl₂ / 0 °C

5.1: HCl / diethyl ether

5.2: diphenylphosphorus azide; NaHCO₃ / dimethylformamide / 0 °C

With hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2004.02.080