N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate

Base Information

• Chemical Name: N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate
• CAS No.: 365432-05-9
• Molecular Formula: C₁₇H₂₁ClN₃O₇P
• Molecular Weight: 445.796

Synonyms:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate

Chemical Property of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate

Chemical Property:

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Technology Process of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate

There total 7 articles about N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C20H25ClN3O7P (365431-92-1) → N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate (365432-05-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; In tetrahydrofuran; at 20 ℃; for 0.75h;

DOI:10.1021/jm060142p

Reference yield:

N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallyl)phenyl phosphorodiamidic chloride (365431-80-7) → N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate (365432-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / LiHMDS / tetrahydrofuran / 4 h / -20 °C

2: 76 percent / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.75 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jm060142p

Reference yield:

(5-nitrofuran-2-yl)methanol (2493-04-1) → N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxy)phenyl phosphorodiamidate (365432-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / LiHMDS / tetrahydrofuran / 4 h / -20 °C

2: 76 percent / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.75 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jm060142p

upstream raw materials:

C₂₀H₂₅ClN₃O₇P

N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallyl)phenyl phosphorodiamidic chloride

(5-nitrofuran-2-yl)methanol

4-aminobenzoic acid allyl ester

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