[2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester

Base Information

• Chemical Name: [2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester
• CAS No.: 1027935-93-8
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.314
• Mol file: 1027935-93-8.mol

Synonyms:[2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester

Chemical Property of [2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester

There total 1 articles about [2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl N-(2-bromoethyl)carbamate (7452-78-0) + 3,5-dimethylaminoaniline (108-69-0) → [2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester (1027935-93-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 24h;

DOI:10.1021/jm960372b

Reference yield:

[2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester (1027935-93-8) → C13H19N3O3

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 5 ℃; for 2h;

DOI:10.1021/jm960372b

Reference yield:

[2-(3,5-Dimethyl-phenylamino)-ethyl]-carbamic acid ethyl ester (1027935-93-8) → 1-(3,5-Dimethyl-phenyl)-[1,2,4]triazinan-3-one

Guidance literature:

Multi-step reaction with 3 steps

1: HCl, NaNO₂ / H₂O / 2 h / 5 °C

2: Zn (dust), acetic acid / H₂O / 1 h / 30 °C

3: EtMgBr / CH₂Cl₂; tetrahydrofuran / 1.) -40 deg C, 0.5 h, 2.) 40 deg C, 48 h

With hydrogenchloride; ethylmagnesium bromide; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm960372b

upstream raw materials:

ethyl N-(2-bromoethyl)carbamate

3,5-dimethylaminoaniline

Downstream raw materials:

{2-[N-(3,5-Dimethyl-phenyl)-hydrazino]-ethyl}-carbamic acid ethyl ester