(3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

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Chemical Name:(3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione
CAS No.:137238-51-8
Molecular Formula:C₂₃H₃₉N₃O₇
Molecular Weight:469.579
Hs Code.:

Synonyms:(3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

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Chemical Property of (3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

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Technology Process of (3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

There total 19 articles about (3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143614-44-2
(2R,9S,12S,13R)-12-(cyclohexylmethyl)-13-hydroxy-2-(4-morpholinomethyl)-9-<<(phenylmethoxy)carbonyl>amino>-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane

: 137238-51-8
(3R,4S,7S,14R)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1021/jm00099a004

Reference yield:

: 143614-45-3
(2S,9S,12S,13R)-12-(cyclohexylmethyl)-13-hydroxy-2-(4-morpholinomethyl)-9-<<(phenylmethoxy)carbonyl>amino>-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane

: 137238-51-8
(3R,4S,7S,14S)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1021/jm00099a004

Reference yield:

: 137238-59-6
5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester

: 137238-51-8
(3R,4S,7S,14R)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

Guidance literature:: Multi-step reaction with 6 steps

1: 36 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

2: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

3: hydroxybenzotriazole monohydrate (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC), N-methylmorpholine (NMM) / CH₂Cl₂ / 0 - 20 °C

4: H₂ / 10 percent Pd/C / methanol / 760 Torr

5: 4-(dimethylamino)pyridine (DMAP), 4-(dimethylamino)pyridine hydrochloride, 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / tetrahydrofuran; CHCl₃ / 19 h / Heating

6: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; dmap; hydrogen; 4-(dimethylamino)pyridine hydrochloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1021/jm00099a004