(R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Base Information

Chemical Name:(R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid
CAS No.:137238-65-4
Molecular Formula:C₂₈H₄₉N₃O₁₀
Molecular Weight:587.711
Hs Code.:

Synonyms:(R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Suppliers and Price of (R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

There total 7 articles about (R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143508-36-5
(1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(phenylmethoxy)propanoyl>amino>butanoate

: 137238-65-4
(R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1021/jm00099a004

Reference yield:

: 137238-88-1
4-Oxiranyl-butyric acid benzyl ester

: 137238-65-4
(R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: alumina / diethyl ether

2: 36 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

3: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

4: hydroxybenzotriazole monohydrate (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC), N-methylmorpholine (NMM) / CH₂Cl₂ / 0 - 20 °C

5: H₂ / 10 percent Pd/C / methanol / 760 Torr

With 4-methyl-morpholine; dmap; aluminum oxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00099a004

Reference yield:

: 137238-59-6
5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester

: 137238-65-4
(R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

2: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

3: hydroxybenzotriazole monohydrate (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC), N-methylmorpholine (NMM) / CH₂Cl₂ / 0 - 20 °C

4: H₂ / 10 percent Pd/C / methanol / 760 Torr

With 4-methyl-morpholine; dmap; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00099a004