2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

Base Information

Chemical Name:2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide
CAS No.:1065080-96-7
Molecular Formula:C₁₆H₁₁Cl₂N₅O
Molecular Weight:360.202
Hs Code.:

Synonyms:2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

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Chemical Property of 2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

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Technology Process of 2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

There total 5 articles about 2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065082-99-6
6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-amine

: 372-09-8
cyanoacetic acid

: 1065080-96-7
2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

Guidance literature:: With diisopropyl-carbodiimide; In tetrahydrofuran; for 1h; Heating / reflux;

Reference yield:

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1065080-96-7
2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / hexanes; dichloromethane / 2 h / -78 °C

2.2: 0.33 h

2.3: 1 h / 75 °C

3.1: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 0.5 h / 0 °C

4.1: hydrogenchloride; iron / ethanol; water / 0.5 h / 60 °C

5.1: diisopropyl-carbodiimide / tetrahydrofuran / 1 h / Heating / reflux

With hydrogenchloride; tetrabutylammonium nitrate; iron; sodium hydride; diisobutylaluminium hydride; trifluoroacetic anhydride; diisopropyl-carbodiimide; In tetrahydrofuran; hexanes; ethanol; dichloromethane; water;

Reference yield:

: 1065082-93-0
6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidine

: 1065080-96-7
2-cyano-N-[6-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-3-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 0.5 h / 0 °C

2: hydrogenchloride; iron / ethanol; water / 0.5 h / 60 °C

3: diisopropyl-carbodiimide / tetrahydrofuran / 1 h / Heating / reflux

With hydrogenchloride; tetrabutylammonium nitrate; iron; trifluoroacetic anhydride; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; water;