1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

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Chemical Name:1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene
CAS No.:318262-30-5
Molecular Formula:C₃₂H₄₂O₈
Molecular Weight:554.681
Hs Code.:

Synonyms:1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

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Chemical Property of 1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

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Technology Process of 1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

There total 16 articles about 1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 318262-29-2
[3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-phenylethynyl]-trimethyl-silane

: 318262-30-5
1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

Guidance literature:: With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 20 ℃; for 0.00833333h;
DOI:10.1021/ja002129e

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 318262-30-5
1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

Guidance literature:: Multi-step reaction with 10 steps

1: 85 percent / BH₃*THF / tetrahydrofuran / 16 h / 20 °C

2: 92 percent / PCl₅ / CHCl₃ / 12 h / Heating

3: 84 percent / Bu₄NI; aq. NaOH / CH₂Cl₂ / 24 h / 20 °C

4: 90 percent / hydrazine hydrate; graphite / ethanol / 11 h / Heating

5: 98 percent / BF₃*OEt₂; t-butyl nitrite / tetrahydrofuran / -15 °C

6: 93 percent / K₂CO₃ / CH₂Cl₂ / 1 h / 0 °C

7: 80 percent / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 41 h / 70 °C

8: 80 percent / CH₃I / 12 h / 110 °C

9: 84 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 70 °C

10: 98 percent / TBAF; H₂O / tetrahydrofuran / 0.01 h / 20 °C

With sodium hydroxide; copper(l) iodide; tert.-butylnitrite; borane-THF; phosphorus pentachloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; pyrographite; hydrazine hydrate; triethylamine; triphenylphosphine; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; chloroform; 7: Sonogashira coupling;
DOI:10.1021/ja002129e

Reference yield:

: 318261-49-3
1-bromo-3-(chloromethyl)-5-nitrobenzene

: 318262-30-5
1-Ethynyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-5-(3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxymethyl}-phenylethynyl)-benzene

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / Bu₄NI; aq. NaOH / CH₂Cl₂ / 24 h / 20 °C

2: 90 percent / hydrazine hydrate; graphite / ethanol / 11 h / Heating

3: 98 percent / BF₃*OEt₂; t-butyl nitrite / tetrahydrofuran / -15 °C

4: 93 percent / K₂CO₃ / CH₂Cl₂ / 1 h / 0 °C

5: 80 percent / CuI; PPh₃; Et₃N / Pd₂(dba)3 / 41 h / 70 °C

6: 80 percent / CH₃I / 12 h / 110 °C

7: 84 percent / CuI; PPh₃; NEt₃ / Pd₂(dba)3 / 70 °C

8: 98 percent / TBAF; H₂O / tetrahydrofuran / 0.01 h / 20 °C

With sodium hydroxide; copper(l) iodide; tert.-butylnitrite; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; pyrographite; hydrazine hydrate; triethylamine; triphenylphosphine; methyl iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; 5: Sonogashira coupling;
DOI:10.1021/ja002129e