tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

Base Information

Chemical Name:tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate
CAS No.:1598383-45-9
Molecular Formula:C₃₈H₅₂N₄O₆
Molecular Weight:660.854
Hs Code.:

tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

Synonyms:tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

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Chemical Property of tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

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Technology Process of tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

There total 5 articles about tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.8%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1598383-46-0
C₃₀H₄₂N₂O₆

: 1598383-45-9
tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₃₀H₄₂N₂O₆; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 1598383-43-7
methyl 5-(((trans)-4-((tert-butoxycarbonyl)-amino)-cyclohexyl)-(ethyl)amino)-4'-hydroxy-4-methyl-[1,1'-biphenyl]-3-carboxylate

: 1598383-45-9
tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / acetonitrile / 12 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

3.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

With water; caesium carbonate; triethylamine; sodium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1403258-27-4
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

: 1598383-45-9
tert-butyl ((trans)-4-((5-(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4'-(2-methoxyethoxy)-4-methyl-[1,1'-biphenyl]-3-(ethyl)(amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2.1: caesium carbonate / acetonitrile / 12 h / 80 °C

3.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

4.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; caesium carbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; acetonitrile;