7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

Base Information

Chemical Name:7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one
CAS No.:1065113-99-6
Molecular Formula:C₂₃H₂₅N₃O
Molecular Weight:359.471
Hs Code.:

Synonyms:7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

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Chemical Property of 7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

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Technology Process of 7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

There total 2 articles about 7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 108168-90-7
2-(4-methylphenyl)ethanimidamide hydrochloride

: 19786-57-3
ethyl 1-benzyl-5-oxoazepane-4-carboxylate hydrochloride

: 1065113-99-6
7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

Guidance literature:: 2-(4-methylphenyl)ethanimidamide hydrochloride; ethyl 1-benzyl-5-oxoazepane-4-carboxylate hydrochloride; With ethanol; sodium; Heating / reflux;

With hydrogenchloride; In water;

With sodium hydrogencarbonate; In water;

Reference yield:

: 108168-90-7
2-(4-methylphenyl)ethanimidamide hydrochloride

: 19673-12-2
1-benzyl-5-oxo-azepane-4-carboxylic acid ethyl ester

: 1065113-99-6
7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

Guidance literature:: With sodium ethanolate; In ethanol; for 18h; Reflux;
DOI:10.1016/j.bmcl.2010.11.120

Reference yield:

: 1065113-99-6
7-benzyl-2-(4-methylbenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

: 1065114-04-6
7-benzyl-4-chloro-2-(4-methylbenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

Guidance literature:: With tetraethylammonium chloride; trichlorophosphate; In propiononitrile; at 100 ℃; for 18h;
DOI:10.1016/j.bmcl.2010.11.120