methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Base Information

Chemical Name:methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate
CAS No.:1323410-38-3
Molecular Formula:C₂₇H₃₄N₄O₅
Molecular Weight:494.591
Hs Code.:

Synonyms:methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Suppliers and Price of methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

There total 11 articles about methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1323407-16-4
4-carbamoyl-4-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid methyl ester

: 622381-65-1
(4-(4-methyl piperazin-1-ylmethyl)phenyl)-methanol

: 1323410-38-3
methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Guidance literature:: 4-carbamoyl-4-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid methyl ester; With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

(4-(4-methyl piperazin-1-ylmethyl)phenyl)-methanol; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 1323290-64-7
methyl 4,5-diamino-5-oxo-pentanoate hydrochloride

: 1323410-38-3
methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; water / 15 h / 15 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 0 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 603-80-5
3-hydroxy 2-methylbenzoic acid

: 1323410-38-3
methyl 5-amino-4-(4-((4-((4-methylpiperazin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 17 h / 65 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 1 h / 25 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / ethyl acetate / 2 h / 65 °C / Inert atmosphere; Irradiation

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide; water / 15 h / 15 °C / Inert atmosphere

5.2: 0.17 h / 20 °C / Inert atmosphere

6.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.2: 3 h / 0 °C / Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928