603-80-5

Usage

Chemical Properties

Light Yellow Crystalline Solid

Uses

3-Hydroxy-2-methylbenzoic Acid (cas# 603-80-5) is a compound useful in organic synthesis.

InChI:InChI=1/C8H8O3/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4,9H,1H3,(H,10,11)/p-1

Upstream product

• 489-78-1 1-amino-5-hydroxynaphthalene-7-sulphonic acid 
• 38251-40-0 5-amino-naphthalene-1,7-disulfonic acid 
• 6654-64-4 naphthalene-1,3,5-trisulphonic acid 
• 131-27-1 3-amino-1,5-naphthalenedisulfonic acid 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 24487-91-0 3-methoxy-2-methylbenzoyl chloride 
• 52130-17-3 3-amino-2-methylbenzoic acid 
• 60-29-7 diethyl ether 
• 7664-93-9 sulfuric acid 
• 18583-89-6 methyl 3-amino-2-methylbenzoate 
• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 133232-56-1 3-iodo-2-methylbenzoic acid 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 

Downstream Products

• 141607-09-2 ethyl 3-hydroxy-2-methylbenzoate 
• 90113-38-5 3t-hydroxy-2ξ-methyl-cyclohexane-rcarboxylic acid 
• 95-48-7 ortho-cresol 
• 42981-93-1 3-methoxy-2-methylbenzoic acid methyl ester 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 186537-85-9 KNI-577 

Relevant academic research and scientific papers

Synthesis process 2 - methyl -3 - methoxybenzoic acid

The invention discloses a synthesis process of 2 - methyl -3 - methoxybenzoic acid, which comprises the following steps: (1) reducing hydrogenation reaction: taking 2 - methyl -3 - nitrobenzoic acid or 2 - methyl -3 - nitrobenzoate as raw materials and methanol as a solvent. The hydrogen is a hydrogen source, and palladium carbon or platinum carbon is used as a catalyst to prepare 3 - amino -2 - methyl benzoic acid or 3 - amino -2 - methyl benzoic acid methyl ester by hydrogenation reduction. (2) Diazotization and hydrolysis and esterification one-pot reaction: preparing and hydroxyl 3 - methyl benzoic acid methyl ester by carrying out diazotization and hydrolysis -2 - esterification reaction under the action of a reducing product as a raw material and methanol as a solvent and a diazotization reagent. (3) Methylation reaction: methyl benzoate serving 3 - hydroxyl -2 - is used as a raw material, dimethyl sulfate is used as a methylation reagent, and methyl benzoate is produced 3 - methoxy -2 - methyl benzoate in the presence of a base. (4) Hydrolysis Reaction: methyl 3 - methoxy -2 - methyl benzoate and base. Water is mixed, heated and hydrolyzed, the reaction is complete, the product precipitated by acid conditioning PH through 1-3, filtered, and dried to obtain 3 - methoxy -2 -methylbenzoic acid.

Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air

L-(?)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95percent ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.

Application of quebrachitol in hydrolysis reaction of copper-catalyzed aryl halide

The invention belongs to the technical field of drug synthesis, and provides application of quebrachitol in a hydrolysis reaction of a copper-catalyzed aryl halide. According to the hydrolysis reaction, copper serves as a catalyst, quebrachitol serves as a ligand, and the hydrolysis reaction is carried out on the aryl halide. The invention further provides a catalytic system of the hydrolysis reaction of the aryl halide. The reaction system comprises the copper catalyst, the quebrachitol, alkali and water, and the system is environmentally friendly and is suitable for industrial application.

Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators

This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor agonists, and which are represented by Formula I: wherein R1, R2, R3, R4, R5, A, and B are as defined in the specification, and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

Process for making 2-alkyl-3-hydroxybenzoic acids

A two step process is described for making 2-alkyl-3-hydroxybenzoic acids or derivatives of benzoic acids by first reacting an allenyl ester or equivalent with furan followed by the ring-opening reaction of the derived bicyclo intermediate with base. The

Process for synthesizing benzoic acids

A nucleophilic substitution reaction on optionally substituted dihalobenzenes is carried out in the presence of an optional catalyst followed by formation of and subsequent carboxylation of a Grignard reaction intermediate. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, formyloxybenzoic and alkoxybenzoic acids from 1-substituted 2,6-dihalobenzenes. The invention also provides a process for the direct formation of an acyl chloride from a Grignard reagent by quenching with phosgene.

Benzodioxincarboxylic acid hydrazides as insecticides

The present invention is concerned with benzodioxincarboxylic acids and esters, N'-substituted N,N'-diacylhydrazines prepared from benzodioxincarboxylic acids and esters, insecticidal compositions containing the N'-substituted N,N'-diacylhydrazines, and t

Bicyclic inhibitors of protein farnesyl transferase

PCT No. PCT/US98/03025 Sec. 371 Date Aug. 2, 1999 Sec. 102(e) Date Aug. 2, 1999 PCT Filed Feb. 11, 1998 PCT Pub. No. WO98/34921 PCT Pub. Date Aug. 13, 1998The present invention provides compounds of Formula (I). The present invention also provides a metho

Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors

PCT No. PCT/US94/09139 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 23, 1994 PCT Pub. No. WO95/06030 PCT Pub. Date Mar. 2, 1995The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as human immunodeficiency virus.

Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors

PCT No. PCT/US96/00607 Sec. 371 Date Feb. 26, 1998 Sec. 102(e) Date Feb. 26, 1998 PCT Filed Jan. 18, 1996 PCT Pub. No. WO96/22287 PCT Pub. Date Jul. 25, 1996Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein the variables are as defined herein.