603-80-5

Basic information

• Product Name: 3-Hydroxy-2-methylbenzoic acid
• Synonyms: 2-Methyl-3-hydroxybenzoicacid;HMBA;3-HYDROXY-O-TOLUIC ACID;3-HYDROXY-2-TOLUIC ACID;3-HYDROXY-2-METHYLBENZOIC ACID;Hydroxytoluicacid,98%;3,2-Cresotic Acid;NSC 73133
• CAS NO: 603-80-5
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.15
• EINECS: -0
• Product Categories: Acids and Derivatives;Alcohols and Derivatives;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Aromatics Compounds;Aromatics;Pesticide Intermediate;Nelfinavir Mesylate
• Mol File: 603-80-5.mol
• Article Data: 23

Chemical Properties

• Melting Point: 143-148°C
• Boiling Point: 336.6 °C at 760 mmHg
• Flash Point: 171.6 °C
• Appearance: Light yellow crystalline solid
• Density: 1.304 g/cm³
• Vapor Pressure: 4.36E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.83±0.10(Predicted)
• BRN: 2613791
• CAS DataBase Reference: 3-Hydroxy-2-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-2-methylbenzoic acid(603-80-5)
• EPA Substance Registry System: 3-Hydroxy-2-methylbenzoic acid(603-80-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 603-80-5(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Crystalline Solid

Uses

3-Hydroxy-2-methylbenzoic Acid (cas# 603-80-5) is a compound useful in organic synthesis.

InChI:InChI=1/C8H8O3/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4,9H,1H3,(H,10,11)/p-1

Upstream product

• 38251-40-0 5-amino-naphthalene-1,7-disulfonic acid 
• 6654-64-4 naphthalene-1,3,5-trisulphonic acid 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 24487-91-0 3-methoxy-2-methylbenzoyl chloride 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 489-78-1 1-amino-5-hydroxynaphthalene-7-sulphonic acid 
• 18583-89-6 methyl 3-amino-2-methylbenzoate 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 133232-56-1 3-iodo-2-methylbenzoic acid 
• 170240-13-8 Ethyl (+/-)-3-methylene-7-oxabicyclo<2.2.1>hept-5-ene-2-carboxylate 
• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 60-29-7 diethyl ether 
• 7664-93-9 sulfuric acid 

Downstream Products

• 141607-09-2 ethyl 3-hydroxy-2-methylbenzoate 
• 55289-05-9 methyl 3-hydroxy-2-methylbenzoate 
• 186537-85-9 KNI-577 
• 95-48-7 ortho-cresol 
• 1025925-78-3 N'-[2-(3-hydroxy-2-methyl-benzoylamino)-4-methyl-pentanoyl]-N'-phenyl-hydrazinecarboxylic acid tert-butyl ester 
• 1026405-62-8 N'-[3-hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-butyryl]-N'-phenyl-hydrazinecarboxylic acid tert-butyl ester 
• 1026936-55-9 N'-[2-(3-hydroxy-2-methyl-benzoylamino)-4-methylsulfanyl-butyryl]-N'-phenyl-hydrazinecarboxylic acid tert-butyl ester 
• 1027268-01-4 N'-benzyl-N'-[2-(3-hydroxy-2-methyl-benzoylamino)-4-methyl-pentanoyl]-hydrazinecarboxylic acid tert-butyl ester 
• 1027189-60-1 N'-benzyl-N'-[2-(3-hydroxy-2-methyl-benzoylamino)-4-methylsulfanyl-butyryl]-hydrazinecarboxylic acid tert-butyl ester 
• 1025932-55-1 N'-benzyl-N'-[3-hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-butyryl]-hydrazinecarboxylic acid tert-butyl ester 
• 862891-04-1 (E)-(S)-4-{(S)-3-Hydroxy-2-[(S)-2-(3-hydroxy-2-methyl-benzoylamino)-3-methyl-butyrylamino]-propionylamino}-6-methyl-hept-2-enoic acid ethyl ester 
• 1403597-59-0 3-hydroxy-2-methyl-4-nitrobenzoic acid 
• 330191-68-9 5-(4-Hydroxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl)-2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid 
• 55-21-0 benzamide 

Relevant articles and documents

Synthesis process 2 - methyl -3 - methoxybenzoic acid

The invention discloses a synthesis process of 2 - methyl -3 - methoxybenzoic acid, which comprises the following steps: (1) reducing hydrogenation reaction: taking 2 - methyl -3 - nitrobenzoic acid or 2 - methyl -3 - nitrobenzoate as raw materials and methanol as a solvent. The hydrogen is a hydrogen source, and palladium carbon or platinum carbon is used as a catalyst to prepare 3 - amino -2 - methyl benzoic acid or 3 - amino -2 - methyl benzoic acid methyl ester by hydrogenation reduction. (2) Diazotization and hydrolysis and esterification one-pot reaction: preparing and hydroxyl 3 - methyl benzoic acid methyl ester by carrying out diazotization and hydrolysis -2 - esterification reaction under the action of a reducing product as a raw material and methanol as a solvent and a diazotization reagent. (3) Methylation reaction: methyl benzoate serving 3 - hydroxyl -2 - is used as a raw material, dimethyl sulfate is used as a methylation reagent, and methyl benzoate is produced 3 - methoxy -2 - methyl benzoate in the presence of a base. (4) Hydrolysis Reaction: methyl 3 - methoxy -2 - methyl benzoate and base. Water is mixed, heated and hydrolyzed, the reaction is complete, the product precipitated by acid conditioning PH through 1-3, filtered, and dried to obtain 3 - methoxy -2 -methylbenzoic acid.

Application of quebrachitol in hydrolysis reaction of copper-catalyzed aryl halide

The invention belongs to the technical field of drug synthesis, and provides application of quebrachitol in a hydrolysis reaction of a copper-catalyzed aryl halide. According to the hydrolysis reaction, copper serves as a catalyst, quebrachitol serves as a ligand, and the hydrolysis reaction is carried out on the aryl halide. The invention further provides a catalytic system of the hydrolysis reaction of the aryl halide. The reaction system comprises the copper catalyst, the quebrachitol, alkali and water, and the system is environmentally friendly and is suitable for industrial application.

Process for making 2-alkyl-3-hydroxybenzoic acids

A two step process is described for making 2-alkyl-3-hydroxybenzoic acids or derivatives of benzoic acids by first reacting an allenyl ester or equivalent with furan followed by the ring-opening reaction of the derived bicyclo intermediate with base. The