N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Base Information

Chemical Name:N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide
CAS No.:925673-29-6
Molecular Formula:C₃₈H₅₃NO₄
Molecular Weight:587.843
Hs Code.:

Synonyms:N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

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Chemical Property of N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

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Technology Process of N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

There total 13 articles about N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 925673-28-5
N-butyl-N-methyl-7-(3-benzyloxy-2-iodo-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

: 124-41-4
sodium methylate

: 925673-29-6
N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Guidance literature:: With copper(l) iodide; 15-crown-5; In methanol; N,N-dimethyl-formamide; at 120 ℃; for 12h;
DOI:10.1016/j.bmc.2006.10.055

Reference yield:

: 925673-19-4
7-(3,17β-dihydroxyestra-1,3,5(10),6(7)-teraen-6-yl)heptanol

: 925673-29-6
N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / Pd-C / ethyl acetate / 4.5 h / 20 °C

2.1: Jones' reagent / acetone / 0.33 h / 20 °C

3.1: tributylamine / CH₂Cl₂ / 0.67 h / -10 °C

3.2: 50 percent / CH₂Cl₂ / 3 h / 20 °C

4.1: 96 percent / K₂CO₃ / methanol; H₂O / 3 h / 20 °C

5.1: 100 percent / cesium carbonate / acetonitrile / 2.5 h / Heating

6.1: 85 percent / I₂; CF₃CO₂Ag; NaHCO₃ / CH₂Cl₂ / 4 h / -40 °C

7.1: 66 percent / 15-crown-5; CuI / methanol; dimethylformamide / 12 h / 120 °C

With copper(l) iodide; jones' reagent; 15-crown-5; tributyl-amine; hydrogen; iodine; silver trifluoroacetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmc.2006.10.055

Reference yield:

: 925893-08-9
3,17β-bis(tetrahydro-2H-pyran-2-yloxy)-6-[7-(tetrahydro-2H-pyran-2-yloxy)heptyl]estra-1,3,5(10)-trien-6-ol

: 925673-29-6
N-butyl-N-methyl-7-(3-benzyloxy-2-methoxy-17-oxoestra-1,3,5(10)-trien-6β-yl)heptanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 72 percent / hydrochloric acid / ethanol / 1 h / Heating

2.1: H₂ / Pd-C / ethyl acetate / 4.5 h / 20 °C

3.1: Jones' reagent / acetone / 0.33 h / 20 °C

4.1: tributylamine / CH₂Cl₂ / 0.67 h / -10 °C

4.2: 50 percent / CH₂Cl₂ / 3 h / 20 °C

5.1: 96 percent / K₂CO₃ / methanol; H₂O / 3 h / 20 °C

6.1: 100 percent / cesium carbonate / acetonitrile / 2.5 h / Heating

7.1: 85 percent / I₂; CF₃CO₂Ag; NaHCO₃ / CH₂Cl₂ / 4 h / -40 °C

8.1: 66 percent / 15-crown-5; CuI / methanol; dimethylformamide / 12 h / 120 °C

With hydrogenchloride; copper(l) iodide; jones' reagent; 15-crown-5; tributyl-amine; hydrogen; iodine; silver trifluoroacetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmc.2006.10.055