(E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene

Base Information

• Chemical Name: (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene
• CAS No.: 1422985-03-2
• Molecular Formula: C₁₀H₈F₃NO₃
• Molecular Weight: 247.174
• Mol file: 1422985-03-2.mol

Synonyms:(E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene

Chemical Property of (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene

There total 2 articles about (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H10F3NO4 (1422984-82-4) → (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene (1422985-03-2)

Guidance literature:

With pyridine; thionyl chloride; In toluene; at 0 - 20 ℃; for 3h;

DOI:10.1021/ja400650m

Reference yield:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone (30724-22-2) → (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene (1422985-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 20 °C

2: thionyl chloride; pyridine / toluene / 3 h / 0 - 20 °C

With pyridine; thionyl chloride; triethylamine; In toluene; 1: |Henry Nitro Aldol Condensation;

DOI:10.1021/ja400650m

Reference yield: 82.0%

tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate (1374605-89-6) + (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene (1422985-03-2) → (R,Z)-tert-butyl 2-oxo-3-(5,5,5-trifluoro-4-(3-methoxyphenyl)-4-(nitromethyl)pentan-2-ylidene)indoline-1-carboxylate (1570104-93-6)

Guidance literature:

With C₂₉H₂₈F₆N₄OS; In toluene; at 20 ℃; for 36h; enantioselective reaction;

DOI:10.1021/ol500157b

upstream raw materials:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone

C₁₀H₁₀F₃NO₄

Downstream raw materials:

3-(1,1,1-trifluoro-2-(3-methoxyphenyl)-3-nitropropan-2-yl)-1H-indole

(S,Z)-tert-butyl 2-oxo-3-(5,5,5-trifluoro-4-(3-methoxyphenyl)-4-(nitromethyl)pentan-2-ylidene)indoline-1-carboxylate

(R,Z)-tert-butyl 2-oxo-3-(5,5,5-trifluoro-4-(3-methoxyphenyl)-4-(nitromethyl)pentan-2-ylidene)indoline-1-carboxylate