1422984-82-4

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 128816-77-3 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanol 
• 75-52-5 nitromethane 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 

Downstream Products

• 1422985-22-5 3-(1,1,1-trifluoro-2-(3-methoxyphenyl)-3-nitropropan-2-yl)-1H-indole 
• 1422985-03-2 (E)-1-methoxy-3-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene 

Relevant academic research and scientific papers

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.

Access to Chiral GABA Analogues Bearing a Trifluoromethylated All-Carbon Quaternary Stereogenic Center through Water-Promoted Organocatalytic Michael Reactions

Water enables the highly challenging enantioselective Michael addition of sterically congested β-trifluoromethyl-β-aryl- or -alkyl-substituted nitroolefins with dithiomalonates. Under on-water conditions, the reaction rates were remarkably accelerated as

Highly enantioselective construction of trifluoromethylated all-carbon quaternary stereocenters via nickel-catalyzed friedel-crafts alkylation reaction

A highly enantioselective Friedel-Crafts alkylation reaction of indoles with β-CF3-β-disubstituted nitroalkenes was achieved using a Ni(ClO4)2-bisoxazoline complex as a catalyst, which afforded indole-bearing chiral compou