[4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile

Base Information

• Chemical Name: [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile
• CAS No.: 297157-02-9
• Molecular Formula: C₁₆H₁₄N₄OS
• Molecular Weight: 310.379

Synonyms:[4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile

Chemical Property of [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile

Chemical Property:

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Technology Process of [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile

There total 1 articles about [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Cyanothioacetamide (7357-70-2) + 4-(chloroacetyl)antipyrine (6630-73-5) → [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile (297157-02-9)

Guidance literature:

With triethylamine; In ethanol; for 3h; Heating;

Reference yield: 92.0%

p-methylbenzenediazonium chloride (2028-84-4) + [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile (297157-02-9) → [4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)thiazol-2-yl]-(p-tolylhydrazono)acetonitrile (1228659-17-3)

Guidance literature:

With sodium acetate; In ethanol; at 0 - 5 ℃; for 6h;

DOI:10.1080/00397910903100726

Reference yield: 79.0%

3-phenyl-pyrazol-5-diazonium chloride + [4-(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]acetonitrile (297157-02-9) → 4-[(1,2-dihydro-1,5-dimethy-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]-2-(3-phenyl-1H-pyrazol-5-ylhydrazono)acetonitrile (297157-04-1)

Guidance literature:

With sodium acetate; In pyridine; ethanol; at 0 - 5 ℃; for 16h;

upstream raw materials:

Cyanothioacetamide

4-(chloroacetyl)antipyrine

Downstream raw materials:

4-[(1,2-dihydro-1,5-dimethy-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl]-2-(3-phenyl-1H-pyrazol-5-ylhydrazono)acetonitrile

4-[(1,2-dihydro-1,5-dimethyl-2-phenyl-3-oxo-3H-pyrazol-4-yl)thiazol-2-yl] 2-(1H-1,2,4-triazol-5-ylhydrazono)acetonitrile

2-[4-(2,3-dimethyl-5-oxo-1-phenyl-(3-pyrazolin-4-yl))-(1,3-thiazol-2-yl)]-3-methylthio-3-sulfanylprop-2-enenitrile

2-[4-(2,3-dimethyl-5-oxo-1-phenyl-(3-pyrazolin-4-yl))-(1,3-thiazol-2-yl)]-3-(phenylamino)-3-thioxopropanenitrile

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