2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

Base Information

Chemical Name:2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one
CAS No.:1380397-34-1
Molecular Formula:C₂₅H₂₀Br₃NO₃
Molecular Weight:622.151
Hs Code.:

Synonyms:2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

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Chemical Property of 2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

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Technology Process of 2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

There total 9 articles about 2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1380397-32-9
2,4,6-tribromo-1-(iodomethyl)benzene

: 1380397-31-8
2,2-dimethyl-3-(2-phenylbenzoyl)-oxazolidin-5-one

: 1380397-34-1
2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

Guidance literature:: 2,2-dimethyl-3-(2-phenylbenzoyl)-oxazolidin-5-one; With potassium hexamethylsilazane; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; at -78 ℃; for 0.00555556h; Inert atmosphere;

2,4,6-tribromo-1-(iodomethyl)benzene; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; at -78 ℃; for 0.161111h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201700110

Reference yield:

: 1380397-32-9
2,4,6-tribromo-1-(iodomethyl)benzene

: 1380397-31-8
2,2-dimethyl-3-(2-phenylbenzoyl)-oxazolidin-5-one

: 2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

: 1380397-34-1
2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

Guidance literature:: 2,4,6-tribromo-1-(iodomethyl)benzene; 2,2-dimethyl-3-(2-phenylbenzoyl)-oxazolidin-5-one; With potassium hexamethylsilazane; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; at -78 ℃; for 0.161111h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; optical yield given as %ee; Inert atmosphere;
DOI:10.1002/anie.201200950

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 1380397-34-1
2,2-dimethyl-3-(2-phenylbenzoyl)-4-(2,4,6-tribromobenzyl)-oxazolidin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / 15 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran; 1,2-dimethoxyethane; toluene / 0.16 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

With trimethylaluminum; potassium hexamethylsilazane; In tetrahydrofuran; 1,2-dimethoxyethane; toluene;
DOI:10.1002/anie.201200950