3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

Base Information

Chemical Name:3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one
CAS No.:1271523-45-5
Molecular Formula:C₁₆H₁₃Cl₂N₃O₂
Molecular Weight:350.204
Hs Code.:

Synonyms:3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

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Chemical Property of 3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

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Technology Process of 3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

There total 12 articles about 3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1271523-41-1
tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

: 1271523-45-5
3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

Guidance literature:: With aluminum (III) chloride; sodium hydrogencarbonate; In methoxybenzene; at 20 - 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 1271523-45-5
3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride; iodine / toluene; mineral oil / 4.25 h / 0 - 10 °C / Inert atmosphere

2: caesium carbonate / 16 h

3: sodium hydride / copper(l) iodide / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 100 °C

5: sodium hydrogencarbonate; aluminum (III) chloride / methoxybenzene / 16 h / 20 - 70 °C / Inert atmosphere

With aluminum (III) chloride; iodine; sodium hydride; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; methoxybenzene; toluene; mineral oil;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1271523-45-5
3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / dichloromethane / 0.5 h / 40 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: tetrahydrofuran / 16 h / 15 - 20 °C / Inert atmosphere

3.1: acetic acid / 27 h / 92 °C / Inert atmosphere

4.1: trichlorophosphate / toluene; N,N-dimethyl-aniline / 16 h / 110 °C / Inert atmosphere

4.2: 25 °C / pH 12

5.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 3.5 h / -50 - -40 °C / Inert atmosphere; 3 ? Molecular sieve

5.2: 36 h / -20 - 30 °C

5.3: pH 8

6.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Autoclave

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 100 °C

8.1: sodium hydrogencarbonate; aluminum (III) chloride / methoxybenzene / 16 h / 20 - 70 °C / Inert atmosphere

With aluminum (III) chloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; trichlorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; acetic acid; methoxybenzene; N,N-dimethyl-aniline; toluene;