tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate
CAS No.:1271523-41-1
Molecular Formula:C₂₉H₂₉Cl₂N₃O₅
Molecular Weight:570.472
Hs Code.:

Synonyms:tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

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Chemical Property of tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

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Technology Process of tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

There total 13 articles about tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1046862-08-1
2-(2,4-dichloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 376584-36-0
[5-chloro-1-(4-methoxy-benzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

: 1271523-41-1
tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 100 ℃; for 2h;

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 1271523-41-1
tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / toluene; mineral oil / 0.33 h / 0 - 20 °C

1.2: 16 h / 20 °C

1.3: 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h

3.1: sodium hydride / copper(l) iodide / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 100 °C

With sodium hydride; sodium carbonate; caesium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1271523-41-1
tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.75 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 100 °C

With potassium tert-butylate; hydrogen; sodium carbonate; N,N-dimethyl-aniline; trichlorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; acetic acid; toluene;