Cyclamic acid

Base Information

• Chemical Name: Cyclamic acid
• CAS No.: 100-88-9
• Deprecated CAS: 45951-45-9
• Molecular Formula: C6H13 N O3 S
• Molecular Weight: 179.24
• Hs Code.: 2929909000
• European Community (EC) Number: 202-898-1
• NSC Number: 760133,220327
• UNII: HN3OFO5036
• DSSTox Substance ID: DTXSID5041809
• Nikkaji Number: J4.986G
• Wikipedia: Cyclamate,Cyclamic_acid
• Wikidata: Q2130929
• NCI Thesaurus Code: C76514
• Metabolomics Workbench ID: 44835
• ChEMBL ID: CHEMBL1206440
• Mol file: 100-88-9.mol

Synonyms:Calcium Cyclamate;Cyclamate;Cyclamate Calcium (2:1) Salt;Cyclamate, Calcium;Cyclamate, Calcium (2:1) Salt, Dihydrate;Cyclamate, Potassium;Cyclamate, Sodium;Cyclamate, Sodium Salt;Cyclamates;Cyclamic Acid;Potassium Cyclamate;Sodium Cyclamate

Chemical Property of Cyclamic acid

Chemical Property:

• Appearance/Colour: white crystals
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 165 - 170 C (Decomposes)
• Refractive Index: 1.529
• Boiling Point: °Cat760mmHg
• PKA: pKa 2.28(H2O t=RT c=0.056) (Uncertain)
• Flash Point: °C
• PSA: 74.78000
• Density: 1.32g/cm³
• LogP: 2.18320
• Storage Temp.: Refrigerator
• Solubility.: dioxane: soluble1g/10 mL, clear, colorless (hot)
• Water Solubility.: 133g/L
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 179.06161445
• Heavy Atom Count: 11
• Complexity: 200

Purity/Quality:

98% ^*data from raw suppliers

N-?CyclohexylsulfamicAcid(CyclamicAcid) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: UN NO.
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Food Additives
• Canonical SMILES: C1CCC(CC1)NS(=O)(=O)O
• Uses: A non-nutritive sweetener.

Technology Process of Cyclamic acid

There total 6 articles about Cyclamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

cyclohexylamine (108-91-8,157973-60-9) → cyclohexylsulfamic acid (100-88-9)

Guidance literature:

With chlorosulfonic acid; In chloroform; for 8h; Ambient temperature;

DOI:10.1021/jo00030a037

Reference yield:

1-nitrocyclohexane (1122-60-7) → cyclohexylsulfamic acid (100-88-9)

Guidance literature:

With sodium dithionite; water; sodium phosphate;

DOI:10.1021/jo01183a011

Reference yield:

N-cyclohexyl-hydroxylamine (2211-64-5) → cyclohexylsulfamic acid (100-88-9)

Guidance literature:

With sulfur dioxide; benzene;

upstream raw materials:

cyclohexylamine

Cyclohexyl isocyanate

N-cyclohexyl-hydroxylamine

1-nitrocyclohexane

Downstream raw materials:

cyclohexanone

tert-butyl alcohol

Refernces

• 1、 White, Emil H.,Li, Min,Lu, Shanzheng. "N-Nitrososulfamates: Sources of Carbonium Ions in Aqueous Media and Substrates in Solid-State Decompositions". . p. 1252 - 1258. Retrieved 2007/10/02.