4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

Base Information

Chemical Name:4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine
CAS No.:1380672-00-3
Molecular Formula:C₂₅H₁₉ClN₆O₄S
Molecular Weight:534.983
Hs Code.:

Synonyms:4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

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Chemical Property of 4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

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Technology Process of 4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

There total 5 articles about 4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.3%

: 1380672-63-8
(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

: 1312919-53-1
N-amino-N'-(2-chlorophenyl)-4-methylsulfonyl-benzamidine

: 1380672-00-3
4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

Guidance literature:: (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid; With trichlorophosphate; In toluene; for 2h; Reflux;

N-amino-N'-(2-chlorophenyl)-4-methylsulfonyl-benzamidine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 4052-30-6
4-methylsulfonylbenzoic acid

: 1380672-00-3
4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 18 h / 20 °C

1.2: 2 h / 20 °C

2.1: trichlorophosphate / benzene / 15 h / Reflux

2.2: 2 h / 20 °C

3.1: trichlorophosphate / toluene / 2 h / Reflux

3.2: 18 h / 20 °C

With thionyl chloride; trichlorophosphate; In dichloromethane; toluene; benzene;

Reference yield:

: 95-51-2
o-chloroaniline

: 1380672-00-3
4-(5-((E)-2-(4-(2-chlorophenyl)-5-(4-(methylsulfonyl)phenyl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 18 h / 20 °C

1.2: 2 h / 20 °C

2.1: trichlorophosphate / benzene / 15 h / Reflux

2.2: 2 h / 20 °C

3.1: trichlorophosphate / toluene / 2 h / Reflux

3.2: 18 h / 20 °C

With thionyl chloride; trichlorophosphate; In dichloromethane; toluene; benzene;