ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate

Base Information

• Chemical Name: ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate
• CAS No.: 110164-38-0
• Molecular Formula: C₂₂H₂₆N₄O₅S
• Molecular Weight: 458.538
• Mol file: 110164-38-0.mol

Synonyms:ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate

Chemical Property of ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate

There total 5 articles about ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

chloroformic acid ethyl ester (541-41-3) + 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,2-d>pyrimidine-2,4-dione (110164-15-3) → ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate (110164-38-0)

Guidance literature:

In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield: 28.0%

ethyl 1-bromoformate (17759-76-1) + 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,2-d>pyrimidine-2,4-dione (110164-15-3) → ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate (110164-38-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1021/jm00117a019

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → ethyl 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,2-d]pyrimidine-1-carboxylate (110164-38-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / toluene / 3 h / Heating

2: 67 percent / NaHCO₃, NaI / tetrahydrofuran / 60 h / Heating

3: 72 percent / KOH / methanol / 1 h / Heating

4: 28 percent / NaH / dimethylformamide / 16 h / Ambient temperature

With potassium hydroxide; sodium hydride; sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00117a019

upstream raw materials:

ethyl 1-bromoformate

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,2-d>pyrimidine-2,4-dione

Methyl 3-aminothiophene-2-carboxylate

methyl 3-thiophene-2-carboxylate