2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

Base Information

Chemical Name:2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd
CAS No.:1453861-36-3
Molecular Formula:C₃₁H₃₄O₆
Molecular Weight:502.607
Hs Code.:

Synonyms:2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

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Chemical Property of 2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

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Technology Process of 2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

There total 6 articles about 2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

: 1453861-35-2
ethyl 2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

: 1453861-36-3
2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

Guidance literature:: With methanol; lithium hydroxide; In tetrahydrofuran; for 6h;

Reference yield:

: 1453862-20-8
ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate

: 1453861-36-3
2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 80 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

4: methanol; lithium hydroxide / tetrahydrofuran / 6 h

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 124391-75-9,124506-31-6,15833-61-1
3-tetrahydrofuranmethanol

: 1453861-36-3
2-(3-(4-((2',6'-dimethyl-4'-((tetrahydrofuran-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic aicd

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.08 h / 0 °C

1.2: 2 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: methanol; lithium hydroxide / tetrahydrofuran / 6 h

With methanol; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;