(S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester
• CAS No.: 926623-04-3
• Molecular Formula: C₂₇H₂₈N₂O₇S
• Molecular Weight: 524.595
• Mol file: 926623-04-3.mol

Synonyms:(S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester

Chemical Property of (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester

There total 2 articles about (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Cbz-(L)-Glu-OBn (3705-42-8) + Tosyl isocyanate (4083-64-1) → (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester (926623-04-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2006.11.158

Reference yield:

Cbz-(L)-Glu-OBn (3705-42-8) + toluene-4-sulfonamide (70-55-3) → (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester (926623-04-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jm9803727

Reference yield: 95.0%

trimethoxonium tetrafluoroborate (420-37-1) + (S)-2-Benzyloxycarbonylamino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid benzyl ester (926623-04-3) → 2-benzyloxycarbonylamino-5-[methyl-(toluene-4-sulfonyl)-amino]-5-oxo-pentanoic acid benzyl ester (926623-07-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.11.158

upstream raw materials:

Cbz-(L)-Glu-OBn

toluene-4-sulfonamide

Tosyl isocyanate

Downstream raw materials:

(S)-2-Amino-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid

2-benzyloxycarbonylamino-5-[methyl-(toluene-4-sulfonyl)-amino]-5-oxo-pentanoic acid benzyl ester

(S)-2-(4-{[3-(2,2-Dimethyl-propionyloxymethyl)-2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-2-fluoro-benzoylamino)-5-oxo-5-(toluene-4-sulfonylamino)-pentanoic acid